A rapid filtration assay for cyclic nucleotide binding proteins
نویسندگان
چکیده
منابع مشابه
Cyclic nucleotide-binding domains in proteins having diverse functions.
Since the discovery of cAMP in the 1950s and the subsequent identification of cGMP, the role of these second messengers in mediating cellular function has been a major theme of research in biology. An important aspect of this research has been the identification and characterization of cyclic nucleotide receptors. For more than two decades, the bacterial CAMP-regulated catabolite gene activator...
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Cyclic nucleotide-binding domains (CNBDs) that are present in various channel proteins play crucial roles in signal amplification cascades. Although atomic resolution structures of some of those CNBDs are available, the detailed mechanism by which they confer cyclic nucleotide-binding to the ion channel pore remains poorly understood. In this review, we describe structural insights about cyclic...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58224-5